'Science' Publications: CIQTEK EPR Facilitates Research on Catalytic Reactionisms
'Science' Publications: CIQTEK EPR Facilitates Research on Catalytic Reactionisms
November 18, 2024
Recently, the research teams led by Professor Aiwen Lei from Wuhan University and Professor Lin He from Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, made a significant breakthrough in asymmetric urea synthesis. Their research results, titled "Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas"were published in the prestigious international journal "Science"on November 15th.
Publishedin "Science" with the Support of CIQTEKEPR
Unsymmetrical ureas are important compounds widely used in medicine, agriculture, and materials science. The synthesis of unsymmetrical ureas through amine reactions is the most effective method. However, achieving high selectivity in synthesizing unsymmetrical ureas is challenging due to the competitive reactivity of the two amines. So far, no metal-catalyzed method can efficiently and selectively recognize and install multiple amines at the same site.
In their research, the teams deeply analyzed the electron transfer process between copper salts and amines and successfully detected the in situ-generated ammonium radical cation and its captured radical species with DMPO during the reaction. This provided crucial evidence for revealing the copper ion-mediated free radical activation mechanism of secondary amines. Combining the selective nucleophilic activation of primary amines by cobalt catalysts, the teams designed a "synchronous recognition strategy" that achieved efficient carbonylation reactions of a 1:1 molar ratio of two amines, producing highly selective unsymmetrical urea products.
This achievement provides new avenues for the industrial production of unsymmetrical urea compounds and is expected to have broad applications in fields such as medicine and agriculture. It also demonstrates the precise characterization capabilities of theEPR spectrometerdeveloped by CIQTEK, providing strong support for researchers to deepen their understanding of reaction mechanisms and develop innovative synthesis strategies.
The research paper was published in "Science" and can be accessed at the following link:
A "Timely Rain" that Achieves Customer Satisfaction, Scripting a Success Story
Behind this achievement is a story of collaboration between CIQTEKand the research team. In October 2021, an imported EPR spectrometerat the College of Chemistry and Molecular Sciences, Wuhan University, encountered a sudden malfunction.
After contacting the manufacturer, they learned that the repair would take a long time. This posed a challenge for the experimental work of the faculty and students.
In December of the same year, at the invitation of the faculty, engineers from CIQTEKovercame the challenges posed by the pandemic and arrived on-site to troubleshoot the issue. They quickly identified a problem with the magnet power supply and immediately provided a solution.
On the same day, they completed the hardware repair, performance calibration, and standard sample testing, restoring the equipment to normal operation.
The university expressed its gratitude to CIQTEK, stating, "During the instrument failure, our college was unable to use the equipment for experimental work for two months.
The support provided by CIQTEKwas like a 'timely rain,' allowing us to continue with multiple research projects. In this equipment repair, we witnessed the solid and reliable technical expertise of CIQTEK's EPR team and experienced the high sense of responsibility of high-end scientific instrument manufacturers. The team's quick response, strong capabilities, and high efficiency exemplify the model of scientific instrument manufacturers."
In 2023, the Center for Optoelectronic Nanocatalysis and Industrial Applications at the Wuhan University Institute of Advanced Studies introduced theEPR spectrometer, which played a significant role in the team's research. As CIQTEKcontinues to make breakthroughs inEPR spectrometers, the company is also increasing its efforts to cultivate professional talent.
From Technology to Talent, Together Towards an Innovative Future
The achievement is closely related to the in-depth research of the team led by Professor Lei Aiwen at Wuhan University in the field ofElectron Paramagnetic Resonance (EPR)technology. Over the past four months, Lei Aiwen's team has continuously published high-level research papers in "Science"(2 papers), "Nature"and "Nature Chemistry".
CIQTEK, in collaboration with the University of Science and Technology of China and the Instrument Application Demonstration Center of the Chinese Academy of Sciences, has established three major course systems:
v “Advanced EPR Workshop”
v “Spectroscopy Campus Tour”
v “EPR Application Sharing and Exchange Conference.”
Through these courses, which gradually progress in complexity and combine theory with practice, multidisciplinary interaction in Magnetic Resonance Spectroscopyis continuously promoted.
In October of this year, CIQTEKofficially released the world's first AI-EPR Spectrometer, achieving a breakthrough in the field. In the future, with the continuous advancement of EPR technology and ongoing product innovation, this powerful scientific research tool will undoubtedly help more research teams overcome technical barriers and promote continuous original breakthroughs in chemistry, materials, biology, and other fields.
CIQTEK X-band pulse electron paramagnetic resonance (EPR or ESR) spectroscopy EPR100 supports both continuous-wave EPR and pulse EPR functions. In addition to supporting conventional continuous-wave EPR experiments, the EPR100 can also finely control and measure electron spin quantum states using specific pulse sequences. This enables pulse EPR tests such as T1, T2, ESEEM (electron spin echo envelope modulation), HYSCORE (hyperfine sublevel correlation), etc. The EPR100 offers a comprehensive range of optional accessories, such as ENDOR, DEER, TR-EPR, and AWG modules, which fully meet the requirements of all current pulsed experimental modes. When paired with a variable temperature system, it enables the detection of paramagnetic substances at ultralow temperatures. Pulsed EPR provides higher spectral resolution, revealing the hyperfine interactions between electrons and nuclei and delivering more detailed structural information. This capability is irreplaceable and crucial in scientific research areas such as materials science, biomolecular structure analysis, etc.
X-band Benchtop Electron Paramagnetic Resonance or Electron Spin Resonance (EPR, ESR) Spectrometer The CIQTEK EPR200M is a newly designed benchtop EPR spectrometer specializing in the qualitative and quantitative analysis of free radicals, transition metal ions, material doping and defects. It is an excellent research tool for real-time monitoring of chemical reactions, in-depth evaluation of material properties, and exploration of pollutant degradation mechanisms in environmental science. The EPR200M adopts a compact design and highly integrates the microwave source, magnetic field, probe, and main controller, ensuring sensitivity and stability while being compatible with diverse experimental needs. The user-friendly interface allows even first-time users to start quickly, making the EPR instrument truly easy to use. ★ Email our experts for custom solutions, quotes, or detailed brochures: info@ciqtek.com
The CIQTEK EPR200-Plus is a floor-standing EPR spectrometer with enhanced sensitivity for robust continuous wave (CW) EPR measurements. The model can be customized with three different sizes of electromagnets. An upgraded version, CIQTEK EPR300, is another floor-standing CW EPR spectroscopy with higher sensitivity and optional Q-band extension. >> EPR200-Plus Accessories: Dual Mode Resonator, High-temperature System, Liquid Nitrogen Variable Temperature With Cryostat, Liquid helium Variable Temperature, Liquid Helium-free Dry Cryogenic System, Time-resolved EPR System, Goniometers, Irradiation system, Flat cell. Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a powerful analytical method to study the structure, dynamics, and spatial distribution of unpaired electronics in paramagnetic substances. It can provide in-situ and non-destructive information on electron spins, orbitals, and nuclei at the microscopic scale. EPR spectroscopy is particularly useful for studying metal complexes or free radicals so it has important applications in the fields of chemistry, materials, physics, environment, etc.
Modernize your old EPR spectroscopy for the cutting-edge EPR research This Modernize will bring you features including: ▶ Higher Sensitivity: Ultra-low noise microwave source and signal detection technology. ▶ Better Resolution: Precise magnetic field control technology ▶ Excellent Compatibility: Compatible with a wide range of EPR spectrometers. ▶ Fast Delivery: Complete delivery of the modernized hardware within 2 to 6 months. ▶ High-quality Service: On-site installation and 2-year warranty. ★ Email us for more details: info@ciqtek.com
The CIQTEK EPR300 Electron Paramagnetic Resonance (EPR) Spectrometer incorporates the latest microwave technology and an ultra-high-performance signal processing unit, significantly enhancing detection sensitivity and signal-to-noise ratio to an unprecedented level. It enables precise detection and analysis of unpaired electron signals even at extremely low spin concentrations, providing a novel approach for exploring microscopic physical and chemical properties of low-concentration substances such as free radicals and metal ions. Additionally, the EPR300 supports easy upgrades from X Band to Q Band, achieving higher g-value resolution, which is advantageous for detecting anisotropic samples. The EPR300 establishes a solid experimental foundation for cutting-edge research in life sciences, materials science, chemistry, and physics, driving scientific discoveries to new milestones.