EPR Spectroscopy, Electron Paramagnetic Resonance

CIQTEK EPR Spectroscopy Delivered to Cornell University, USA

In January 2024, CIQTEK's benchtop electron paramagnetic resonance spectrometer EPR200M was successfully delivered to Cornell University for research and teaching in the biomedical field. Cornell University researchers have carried out a number of biomedical research and teaching work based on the EPR200M. The product's simple operation experience, accurate test results, and the prompt service of CIQTEK engineers were well received by the users. They sent a letter of thanks after the delivery of the product: "We find the spectrometer very sensitive and convenient in operation". Jess Whittemore from Cornell University used a video to show the process of testing solid, liquid samples using the EPR200M.

CIQTEK EPR200M Spectroscopy Delivered to National University of Singapore

CIQTEK X-Band Benchtop Electron Paramagnetic Resonance Spectroscopy EPR200M was successfully delivered to Prof. Chen Xiaoyuan's group at the National University of Singapore (NUS). CIQTEK EPR helps with diagnosis and treatment integration research Founded in 1905, the National University of Singapore (NUS) is one of the finest research universities in Singapore and ranks among the world's top researchers in the fields of chemistry and materials science. The main research direction of Prof. Chen Xiaoyuan's group, which introduced the CIQTEK EPR200M, is diagnostic and therapeutic integration. The research utilizes nanotechnology to achieve precise delivery of drugs, including small molecule drugs, peptides and mRNAs, etc. Combined with multimodal imaging technology, the group evaluates the tissue distribution and pharmacokinetic process of drugs in vivo and ultimately realizes the integration of diagnosis and treatment. Jianhua Zou, the relevant person in charge of the project team, said: The stability, sensitivity index and data accuracy of the CIQTEK EPR200M product are fully in line with the requirements of the project team's experimental testing. The team will use the device to test the generation or scavenging of a variety of reactive oxygen species, such as monoclinic oxygen, superoxide radicals, hydroxyl radicals, etc. By measuring the changes in the signal parameters of these radical substances, EPR can dynamically and quantitatively monitor the increase or decrease of their concentration in biological samples, so as to test the effectiveness of antioxidant substances in scavenging reactive oxygen species. X-Band Benchtop EPR Spectroscopy | EPR200M The EPR200M is a newly designed and engineered benchtop electron paramagnetic resonance spectrometer. Based on high sensitivity, high stability, and a variety of experimental scenarios, it provides a cost-effective, low-maintenance, simple and easy-to-use experience for every EPR experimental user.

High-level Research Publications with CIQTEK EPR Spectroscopy

We are pleased to announce that the CIQTEK EPR spectroscopy has contributed to over 100 high-level research publications! (The list is shown below in Section #2) Section 1. One of the Selected Results Vanadium-Catalyzed Dinitrogen Reduction to Ammonia via a [V]═NNH2 Intermediate.Journal of the American Chemical Society (2023) Wenshuang Huang, Ling-Ya Peng, Jiayu Zhang, Chenrui Liu, Guoyong Song, Ji-Hu Su, Wei-Hai Fang, Ganglong Cui, and Shaowei Hu Abstract The Earth's atmosphere is rich in N2 (78%), but the activation and conversion of nitrogen have been challenging due to its chemical inertness. The ammonia industry uses high-temperature and high-pressure conditions to convert N2 and H2 to NH3 on the surface of solid catalysts. Under ambient conditions, certain microorganisms can bind and convert N2 to NH3 via Fe(Mo/V)-based nitrogen fixation enzymes. Although great progress has been made in the structure and intermediates of nitrogen fixation enzymes, the nature of N2 binding to the active site and the detailed mechanism of N2 reduction remains uncertain. Various studies on the activation of N2 with transition metal complexes have been carried out to better understand the reaction mechanism and to develop catalysts for ammonia synthesis under mild conditions. However, the catalytic conversion of N2 to NH3 by transition metal complexes remains challenging. Despite the crucial role of vanadium in biological nitrogen fixation, few well-defined vanadium complexes can catalyze the conversion of N2 to NH3. In particular, the V(NxHy) intermediates obtained from the proton/electron transfer reactions of ligated N2 remain unknown. Herein, this paper reports the vanadium metal complex-catalyzed reduction of nitrogen to ammonia and the first isolation and characterization of a neutral hydrazide complex intermediate ([V]=NNH2) from a nitrogen-activated system, with the cyclic conversion process simulated by the reduction of the protonated vanadium amino complex ([V]-NH2) to obtain a dinitrogen compound and release of ammonia. These findings provide unprecedented insights into the mechanism of N2 reduction associated with FeV nitrogen-fixing enzymes by combining theoretical calculations to elucidate the possible conversion of nitrogen to ammonia via the distal pathway in this catalytic system. The group of Prof. Dr. Shaowei Hu at Beijing Normal University is dedicated to the development of transition metal complexes for the activation of inert small molecules. Recently, in collaboration with Prof. Dr. Ganglong Cui's group, we reported the reduction of nitrogen to ammonia catalyzed by vanadium metal complexes through a combination of theoretical calculations and experimental studies. The results of this study were published in the Journal of the American Chemical Society, and Wenshang Huang (M.S. student) and Lingya Peng (Ph. D. student) were the co-first authors of t...